Stretch Mark Prevention During Pregnancy
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Stretch Mark Prevention During Pregnancy
Stretch Mark Prevention
Palmitoyl Tetrapeptide-3 is a synthetic peptide that is a fragment of immunoglobulin G that has been combined with palmitic acid to make it more lipophillic and thus enhance its affinity towards human skin. Palmitoyl Tetrapeptide-3 was discovered through research to learn how to suppress the body's production of interleukins, particularly IL6, since these are the chemical messengers that trigger the body's acute inflammatory response. Inflammation is a function of immunity and is a protective response to injury or destruction of tissue. This is the body's way of walling off the injurious agent and the injured tissue. Under normal circumstances, very little IL6 is secreted and its secretion is strictly controlled. However, as we age this regulation system develops defects, and significant levels of IL6 appear in the plasma even when there is no inflammatory stimulus. This results in high levels of inflammatory proteins in the tissues and a loss of healing potential. This process has been linked with breast cancer, osteoporosis, anemia, autoimmunity and slower tissue regeneration. The hormone DHEA is directly responsible for maintaining the regulation of the production of IL6. This has even been demonstrated in the skin: when DHEA is present in sufficient amounts it is converted into a steroid hormone, androstenediol, which is directly responsible for maintain IL6 production and for maintaining local homeostasis of cytokine and interleukin production. As we age, DHEA is reduced and this directly leads to cytokine deregulation and the over-production of some interleukins and the under-production of others. As mentioned above, IL6 production is increased with negative consequences. Since UV radiation can increase IL6 production by five times, this process can significantly impact the skin.
The researchers' goal thus became to find a peptide that would mimic the effects of DHEA without DHEA's potential for being converted into estrogen, since estrogen is a hormone that is not licensed for cosmetic purposes. Specifically they wanted to find a peptide that would target IL6 and inhibit its production. The results:
2. Palmitoyl Tetrapeptide-3 reduced levels of IL6 after cells were exposed to UV radiation by up to 86% even though IL6 had been increased by about 20 fold by the UV. These results show that Palmitoyl Tetrapeptide-3 is able to affect baseline levels of IL6 as well as modulate the effects of UV-stimulated overproduction of IL6. IL6 is marketed by Sederma as a molecule that can restore cytokine equilibrium, which characterizes youthful skin. 1-800 Patches has chosen to use Palmitoyl Tetrapeptide-3as a synergistic support ingredient to create a more optimum environment for other active ingredients to help restore youthful skin appearance.
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